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International 3Rs Prize now open for applications. £30k prize (£2k personal award) for outstanding science with demonstrable 3Rs impacts.

NC3Rs | 20 Years: Pioneering Better Science
PhD Studentship

Using non-invasive in vivo imaging to address the 3Rs in high-throughput mouse phenotyping

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At a glance

Award date
September 2011 - September 2015
Grant amount
Principal investigator
Dr Mark Lythgoe


University College London


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Application abstract

In the wake of the first draft of the full mouse genome sequence, large-scale mutagenesis programmes are underway that will produce mice with gene knockouts/point mutations for each of the approximately 25,000 genes in the mouse genome. Analysis of these mice in coming years will give new insights into the genetic basis of human disease and biology, as novel genes are identified that impact upon mammalian physiology and morphology. This studentship will develop non-invasive imaging of live mice to reduce the numbers of mice generated in high-throughput mutagenesis programs and start to refine experimental strategies for working with mouse models. We will use non-invasive in-vivo magnetic resonance imaging (MRI), to assess if this imaging technology can help us understand the function of genes within the brain, which will enable us remove major "bottlenecks" in the development of new diagnosis tests for genetic disease and human gene therapies.


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