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Our Project grant scheme is open for applications, supporting the development of new 3Rs approaches and technologies!

NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research

New approach methodologies (NAMs) in toxicology


New approach methodologies (NAMs) - replacement (full and partial) technologies for use in assessing chemical or drug toxicity - hold great promise in providing useful information for chemical hazard and risk assessment. We are leading projects to increase confidence in the use and application of NAMs for regulatory decision making. This will ultimately reduce the current reliance on animal toxicity tests and improve the science and predictivity of safety testing.

2023 workshop: Opportunities for the UK to develop world-leading chemicals regulation

In collaboration with Unilever we brought together over 50 scientists across government departments, large and small industry and academia to discuss the opportunities to develop and implement UK chemicals regulation that is science-led, embraces the latest scientific and technological developments particularly with regards to the use of NAMs, and provides benefit to the UK economy. 

Pathways-based approaches

Using cell-based and computational approaches to investigate how pharmaceuticals and environmental chemicals interact with biological systems, to help predict whether they are harmful to humans and/or the environment. 

You can also read more about our project around applying pathways-based approaches across the biosciences on our project page.

In vitro approaches for carcinogenicity testing

Increasing the use of cell biotransformation assays in regulatory safety assessment to reduce the numbers of in vivo carcinogenicity screens carried out.

You can read more about this project on our project page: In vitro approaches for carcinogenicity testing.

Opportunities and challenges for integrating new in vitro methodologies in nanomaterial hazard testing and risk assessment

Exploring the use of in vitro approaches in the safety assessment of nanomaterials.

You can read more about this project on our project page: Opportunities to apply the 3Rs in the safety assessment of nanomaterials.

Keep up to date with the latest news from the NC3Rs toxicology and regulatory sciences programme.