Carotid artery endothelial growth: a novel in vitro assay Principal Investigator: Dr Atticus Hainsworth, St George's University of London Project grant
Development and validation of mechanisms-based in vitro transformation assays for carcinogen screening Principal Investigator: Professor Robert Newbold, Brunel University Project grant
Inducible SAA transgenic mice: a refined model of human amyloidosis Principal Investigator: Dr Paul Simons, University College London Project grant
Reduction and refinement of murine models of bacterial infection Principal Investigator: Professor Shiranee Sriskandan, Imperial College London Project grant
Development of leucocyte cell lines for immunological research in teleost fish Principal Investigator: Dr Jun Zou, University of Aberdeen Project grant
The development of an in vitro model of central nervous system injury to identify factors which promote repair Principal Investigator: Professor Susan Barnett, University of Glasgow Project grant
Validating a sexual development test using the 3-spined stickleback for addressing the 3Rs in fish toxicity testing Principal Investigator: Dr Ioanna Katsiadaki, Centre for Environment Fisheries and Aquaculture Science Project grant
Development of a mechanistically informative genome-wide, replacement chemicals screening technology Principal Investigator: Professor Andrew Cossins, University of Liverpool Project grant
Refinement of therapeutic intervention in a mouse model of amyotrophic lateral sclerosis Principal Investigator: Dr Andrew Grierson, University of Sheffield Project grant
Pseudoislets as a model system to study beta cell dysfunction in diabetes Principal Investigator: Professor Peter Jones, King's College London Project grant
Modelling the human asthmatic airway by tissue engineering Principal Investigator: Professor Donna Davies, University of Southampton Project grant
Replacement of hamsters with physicochemical analytical methods for Leptospira vaccine batch potency testing Principal Investigator: Dr Nicholas Coldham, Veterinary Laboratories Agency Project grant
A tissue engineering approach to reduce animal use in renal development and renal organ replacement technology Principal Investigator: Professor Jamie Davies, University of Edinburgh Project grant
Reduction, refinement and replacement of animal use by clonal sampling Principal Investigator: Dr Phillip Jones, Hutchison-MRC Research Centre Project grant
Humane endpoints for rodenticide testing Principal Investigator: Dr Alan MacNicoll, Department for Environment Food & Rural Affairs Project grant
Metabolically competent stem cell systems: novel means to implement 3Rs in better drug safety assessment Principal Investigator: Professor Roland Wolf, University of Dundee Project grant
An in vitro model of the human alveolus to predict the efficacy of systemic antifungal therapy Principal Investigator: Professor William Hope, University of Manchester Project grant
Development of a reduced severity rat epilepsy model Principal Investigator: Dr Gavin Woodhall, Aston University Project grant
Non-invasive identification of individual Xenopus by photography and image processing Principal Investigator: Professor Matthew Guille, University of Portsmouth Project grant
In vitro multi-chamber systems for studying neural degeneration processes Principal Investigator: Professor Victor Perry, University of Southampton Project grant