Recreating thrombosis models using tissue-engineered arterial constructs: A novel method to reduce and replace mice used in platelet research Principal Investigator: Dr Alan Harper, Keele University PhD Studentship
The Refining Dog Care online learning platform - a modular learning resource for those working with dogs in research Principal Investigator: Dr Laura Scullion Hall, University of Stirling Skills and Knowledge Transfer grant
Replacing animal models in fungal pathogen research: An in vitro Titan virulence assay for the human fungal pathogen Cryptococcus neoformans Principal Investigator: Dr Elizabeth Ballou, University of Birmingham PhD Studentship
Development of E-Sense: a flexible in vitro platform to determine cardiovascular risk Principal Investigator: Dr Stephen White, Manchester Metropolitan University PhD Studentship
The role of water chemistry in zebrafish welfare and reproducibility of research studies Principal Investigator: Professor Roderic Wilson, University of Exeter Project grant
Using wireless recording technologies to investigate cortical coherence in a mouse model of dementia Principal Investigator: Dr Jonathan Brown, University of Exeter Skills and Knowledge Transfer grant
A live model to study mucociliary clearance in health and disease Principal Investigator: Professor David Thornton, University of Manchester Project grant
A highly sensitive replacement assay for botulinum neurotoxin type B Principal Investigator: Dr Andrew Peden, University of Sheffield Project grant
DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects Contractor: Professor Raymond Pieters, University of Applied Sciences Utrecht (UASU), CRACK IT Challenge
Development and evaluation of the Animal Welfare Assessment Grid (AWAG) Contractor: Mr Mike Dennis, Public Health England, CRACK IT Solution
Novel approach to model Non-Alcoholic Fatty Liver Disease using human Pluripotent Stem Cells Principal Investigator: Dr Carola Morell, University of Cambridge Fellowship
Generating in vitro human optic vesicles to dissect the genetic modifiers affecting ocular maldevelopment Principal Investigator: Dr Mariya Moosajee, University College London PhD Studentship
Development of the chick embryo as a replacement for rodent models of tumour metastasis Principal Investigator: Dr Anne Herrmann, University of Liverpool Fellowship
Galleria mellonella - a novel infection model for Mycobacterium tuberculosis aimed at reducing the number of animals in experimentation Principal Investigator: Professor Paul Langford, Imperial College London PhD Studentship
Identifying more clinically effective analgesic regimens and potential strain differences in pain perception in mice using a novel Operant Pain Assay Principal Investigator: Dr Matt Leach, Newcastle University Project grant
Identifying regulators of tissue regeneration by in vivo imaging in the zebrafish Principal Investigator: Dr Robert Knight, King's College London PhD Studentship
RespiraTox: In silico model for predicting human respiratory irritation Contractor: Dr Sylvia Escher, Fraunhofer ITEM, CRACK IT Challenge
A chicken primary B cell culture model to study the pathogenesis and improve the control of immunosuppressive viruses of poultry Principal Investigator: Dr Andrew Broadbent, The Pirbright Institute Project grant
Ex vivo model for the study of epicardium-targeted therapies Principal Investigator: Dr Paola Campagnolo, University of Surrey Project grant
A comprehensive in silico approach to measure spatio-temporal changes of bone tissue in mouse models of osteoporosis and osteoarthritis Principal Investigator: Dr Enrico Dall'Ara, University of Sheffield Project grant