Quantifying the potential of skin swabbing as a refinement for DNA sampling of laboratory fish Principal Investigator: Dr Will Norton, University of Leicester Project grant
Intestinal organoids as a replacement strategy to unravel early host intestinal epithelia interactions with whipworms Principal Investigator: Dr Maria Duque Correa, Wellcome Trust Sanger Institute Fellowship
Developing human organotypic perfused bioreactors for physiologically reproducible therapeutic compound screening of a tumour microenvironment Principal Investigator: Dr Xiao Wan, University of Oxford Fellowship
A technique to test novel methods of controlling poultry red mite in hens without performing field-scale trials Principal Investigator: Dr Alasdair Nisbet, Moredun Research Institute Project grant
The use of PrP transgenic Drosophila to replace and reduce mice in the bioassay of mammalian prions Principal Investigator: Dr Raymond Bujdoso, University of Cambridge Skills and Knowledge Transfer grant
Validating the cross-species comparative in silico platform (CRISP) Contractor: Dr Will Krawszik, CRACK IT Solution
Development, validation and application of enhanced-welfare technology for wild small mammal research Principal Investigator: Dr Sarah Knowles, University of Oxford Project grant
In silico design and optimisation of novel host-directed therapies Principal Investigator: Dr Reiko Tanaka, Imperial College London PhD Studentship
Organoid and single cell models of bladder cancer Principal Investigator: Professor Margaret Knowles, University of Leeds PhD Studentship
In vitro reconstitution of the polymicrobial community associated with cystic fibrosis airway infections Principal Investigator: Dr Martin Welch, University of Cambridge PhD Studentship
Replacing liver cancer models by modeling human liver cancer in vitro Principal Investigator: Dr Meritxell Huch, University of Cambridge Project grant
Reducing the animal cost of CRISPR/Cas9 mutagenesis Principal Investigator: Dr Ben Davies, University of Oxford Project grant
Development of a biologically-relevant preclinical radiotherapy dosimetry phantom Principal Investigator: Professor Karen Kirkby, University of Manchester PhD Studentship
Investigation of key inflammatory cells & mediators in zebrafish larval tailfin & heart repair/regeneration following resolution of inflammation Principal Investigator: Professor Adriano Rossi, University of Edinburgh PhD Studentship
Developing a novel experimental design and analysis model for longitudinal animal studies with high-dimensional outcomes Principal Investigator: Professor Peter Diggle, Lancaster University PhD Studentship
Dissemination of refinements in mouse experimental stroke models to the scientific community Principal Investigator: Dr Claire Gibson, University of Leicester Skills and Knowledge Transfer grant
Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel Principal Investigator: Dr Luigi Margiotta-Casaluci, Brunel University Strategic grant
Retinal 3D: 3D hiPSC derived laminated retinal model as a tool for toxicology studies Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd, CRACK IT Challenge
Osteo-chip: Microfluidic Automated Platform for Osteoarthritis Drug Screening (MA-PODS) Contractor: Professor Anne Dickinson, Alcyomics Ltd, CRACK IT Challenge
High-throughput in vitro culture system for Cryptosporidium oocysts: replacing animals in research Principal Investigator: Professor Joanne Cable, Cardiff University Skills and Knowledge Transfer grant