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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

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Topic

Model

Impact stories

612 results

Targeted protein degradation as a novel approach to study protein function in human platelets

Principal Investigator: Professor Ingeborg Hers, University of Bristol

PhD Studentship

A novel in vitro reporter system for blood stem cell activity

Principal Investigator: Dr David Kent, University of York

PhD Studentship

Refining the tagging of wild fish and sharks

Principal Investigator: Dr Matthew Witt, University of Exeter

PhD Studentship

Dr Matthew Witt with two boats on grass in the background

Understanding how altered brain metabolism causes mitochondrial disease

Principal Investigator: Dr Joseph Bateman, King's College London

PhD Studentship

Combining a fully synthetic hydrogel with human intestinal organoids to model pathological matrix remodelling in Inflammatory Bowel Disease

Principal Investigator: Professor Eileen Gentleman, King's College London

PhD Studentship

3D bioprinted microtissues to develop patient-specific non-animal technologies (NAT) in cancer drug development

Principal Investigator: Dr Deepali Pal, Northumbria University

PhD Studentship

Deepali Pal using a microscope. A colleague is beside her looking at a screen

Insects as models to study wound healing, infection and the wound microbiome

Principal Investigator: Dr Ronan McCarthy, Brunel University

PhD Studentship

A 3Rs approach to investigate the feto-maternal interface: visualisation of pathogen and antibody in a 3D in vitro human placental model

Principal Investigator: Professor Aras Kadioglu, University of Liverpool

PhD Studentship

Development and validation of 3D in vitro dormant myeloma cell models to reduce and replace animal studies

Principal Investigator: Dr Michelle Lawson, University of Sheffield

PhD Studentship

Live monitoring of foreign-body response in animals by diffuse Raman spectroscopy

Principal Investigator: Professor Ioan Notingher, University of Nottingham

Project grant

Development of a New Human Model of Lung Squamous Cell Carcinoma Progression

Principal Investigator: Dr Carlos Lopez-Garcia, University of Manchester

Project grant

Establishing the novel ex-vivo focal demyelination model of Multiple Sclerosis in other laboratories to reduce and replace live animal use

Principal Investigator: Dr Ben Newland, Cardiff University

Skills and Knowledge Transfer grant

Adoption of a mouse model of veterinary filariasis for preclinical drug testing

Principal Investigator: Dr Joseph Turner, Liverpool School of Tropical Medicine

Skills and Knowledge Transfer grant

A novel Drosophila model of chronic inflammatory lung disease to explore airway damage, inflammation and infection in vivo

Principal Investigator: Dr Helen Weavers, University of Bristol

PhD Studentship

Determining the efficacy and safety of cancer chemotherapeutics for cholangiocarcinoma (CCA) using Human Precision Cut Tissue Slices (hPCTS)

Principal Investigator: Dr Laura Randle, Unviversity of Liverpool

Skills and Knowledge Transfer grant

Using a novel, high welfare in vivo feeding device for poultry red mite and its integration with other novel tools for this parasite

Principal Investigator: Dr Alasdair Nisbet, Moredun Research Institute

Skills and Knowledge Transfer grant

Go North: Expanding the use of the chick embryo model in cancer research to a multiuser facility at the University of Strathclyde

Principal Investigator: Dr Marie Boyd, University of Strathclyde

Skills and Knowledge Transfer grant

A non-protected larval zebrafish model for the investigation of novel strategies to protect against nerve agent-induced toxicity and seizures

Principal Investigator: Dr Matthew Parker, University of Portsmouth

Skills and Knowledge Transfer grant

A stock image of round glass dishes containing blue and green liquid arranged closely together.

Review of animal use requirements in WHO biologics guidelines

Current contact: Dr Elliot Lilley,

Office-led project

Acquisition of the Drosophila model system to understand mechanisms of innate immunity regulation by chromatin dynamics

Principal Investigator: Dr Patrick Varga-Weisz, University of Essex

Skills and Knowledge Transfer grant