Cerebral organoid models for optical investigation of neural circuit dynamics in neurodegenerative diseases Principal Investigator: Professor Simon Schultz, Imperial College London Skills and Knowledge Transfer grant
Replacing in vivo models with the Quasi vivo system to investigate metastatic site priming by tumour cells Principal Investigator: Dr Hannah Harrison, University of Manchester Skills and Knowledge Transfer grant
Identifying and addressing challenges in fish vitellogenin assessment Current contact: Dr Natalie Burden, Office-led project
Generation of functionally mature pancreatic organoids as a replacement strategy for animal-models of pancreatitis and pancreatic cancer Principal Investigator: Dr Jean-Francois Darrigrand, King's College London Fellowship
Understanding brain regeneration in a zebrafish larval model of intracerebral haemorrhage Principal Investigator: Dr Siobhan Crilly, University of Manchester Fellowship
Investigating biomechanical responses in healthy and diseases ageing cartilage - a tissue engineering approach Principal Investigator: Dr Katarzyna Pirog, Newcastle University PhD Studentship
Optimisation and validation of 3D models of progressive human lung fibrosis Principal Investigator: Dr Joseph Bell, University of Southampton Fellowship
INDUCE-seq: a novel tool for next generation risk assessment Principal Investigator: Professor Simon Reed, Cardiff University PhD Studentship
Using ex vivo organotypic cultures to investigate donor cell integration in the gut Principal Investigator: Dr Conor McCann, University College London Project grant
In vitro, off-host, rearing of the poultry red mite to supply parasites for development of new control methods Principal Investigator: Dr Alasdair Nisbet, Moredun Research Institute Project grant
A Drosophila single-cell resource for brain metabolism research Principal Investigator: Dr Alex Gould, The Francis Crick Institute Project grant
Drug risk assessment and repurposing using biomimetic chromatography and body-on-chip technology Principal Investigator: Dr Adriana Tavares, University of Edinburgh PhD Studentship
Establishment of novel macrophage cell lines to study the pathogenesis of respiratory bacterial pathogens in lung alveolar macrophages Principal Investigator: Dr Gyorgy Fejer, University of Plymouth Skills and Knowledge Transfer grant
Direct replacement of secondary antibodies by Affimer proteins Principal Investigator: Dr Christian Tiede, University of Leeds PhD Studentship
Re-evaluating the need for mAb chronic toxicity studies Current contact: Dr Fiona Sewell, Office-led project
Development of a Drosophila-based platform to replace and reduce animal experimentation in epilepsy research Principal Investigator: Dr Manolis Fanto, King's College London Project grant
Cryo-storing research lines of chicken to eliminate breeding and save genetic resources Principal Investigator: Dr Michael McGrew, University of Edinburgh Project grant
Preneoplastic Pancreatic (PanIN) Organoids as an in vitro Model of Pancreatic Cancer Progression Principal Investigator: Dr Pedro Perez-Mancera, University of Liverpool Project grant
Developing stem cell-derived macrophages to study host pathogen interactions and advance strategies to combat globally important disease in the pig Principal Investigator: Dr Thomas Burdon, University of Edinburgh Project grant